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In the analysis of specific diagnostic procedures we observed a trend of increasing risk of breast cancer with increasing number of radiographs before age 20 (P=0.041 for trend) and a non significantly increased risk of breast cancer after more than two fluoroscopies before age 20 (hazard ratio 2.01, 95% confidence interval 0.71 to 5.71, P=0.102 for trend) compared with no exposure (table 5 ). Furthermore, there was a non significantly increased risk of breast cancer after exposure to mammography before age 30 (1.43, 0.85 to 2.40, P=0.040 for trend). We observed an almost twofold risk increase for exposure to more than four radiographs before age 30 (1.83, 0.84 to 4.00, P=0.012 for trend) and for more than four radiographs at ages 30 39 (2.04, 0.85 to 4.90, P=0.101 for trend; data not shown), though this latter category included only six cases. We found no other associations between exposure at ages 30 39 and risk of breast cancer.

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